NFL Predictions: Week 5 Picks for Every Game

Only four weeks into the 2021 NFL season and there is just one unbeaten team remaining. Four fell this past weekend, leaving Arizona as the last one standing. Let's see what's in store for the Cardinals and how the rest of the Week 5 slate shapes up.

The action starts with one of the previous 3-0 teams that lost in Week 4, the Rams, looking to bounce back on the road against another NFC West rival, the Seahawks, on "Thursday Night Football." Week 5 also marks the return of the NFL International Series as the Jets and Falcons face off in London on Sunday morning (9:30 a.m. ET start).

The 1 p.m. ET window features a couple of divisional games (Titans-Jaguars, Lions-Vikings), as well as a couple of intriguing conference-crossover pairings with the Packers taking on the Bengals and the Dolphins and Buccaneers meeting in Tampa.

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Later Sunday afternoon, the aforementioned Cardinals will look to stay undefeated when they host the 49ers while the Giants and Cowboys renew acquaintances in AT&T Stadium. The Browns will be in Los Angeles to face the Chargers in an intra-conference matchup that could have playoff implications in the AFC down the road.

And speaking of the postseason, the "Sunday Night Football" game between Buffalo and Kansas City is not only a replay of last season's AFC Championship Game, but it also could determine where this season's conference title contest is played even though the Chiefs enter this game at 2-2 while the Bills are 3-1.

Week 5 concludes with the two NFL franchises with Baltimore ties — Colts and Ravens — meeting in the Charm City on "Monday Night Football."

So which teams will come out on top in every NFL game in Week 5? Athlon's own Rob Doster (@AthlonDoster), and Ben Weinrib (@benweinrib), along with AthlonSports.com contributors Bryan Fischer (@BryanDFischer) and Aaron Wilson (@AaronWilson_NFL) predict the winners for every game this week:

NFL Week 5 Predictions